Vaginal cancer can recur in the vagina, pelvis, liver, lungs and lymph nodes . Symptoms of recurrent disease include weight loss, vaginal or rectal bleeding, bleeding from the urinary tract, pain in the pelvis, back or leg, leg swelling and the development of a chronic cough.
• If the tumor is confined to the vagina, bladder and/or rectum, a recurrent vaginal carcinoma may be treated by
the removal of the vagina, bladder and/or rectum (pelvic exenteration).
• Locally recurrent unresectable and/or metastatic disease is treated with single chemotherapeutic drugs such as
cisplatin or carboplatin , or combination chemotherapeutic drug regimens such as mitomycin-C + vincristine
bleomycin + cisplatin, or carboplatin or cisplatin + ifosfamide + etoposide .
Investigational
• Various doses and combinations of the different chemotherapeutic drugs are being studied, including cisplatin,
